Hello everybody and welcome to my talk. My name is Daniel Jones. I’m a family nurse practitioner with Holton Direct Care. I’ve been in medicine for about 13 years now. I’ve practiced in cardiac electrophysiology (myocarditis), emergency departments, urgent care, and family medicine. By fate, I became a so-called “covid expert” while we were in the treatment vacuum. Together with my 4 partners, Holton Direct Care has helped thousands of patients find an alternative to the “sick care” system. We consider our practice the Rebel Alliance in the healthcare universe.
Please don’t record this discussion. I’ll provide access to this presentation on the MWPN website. I’m not sure how long this will go on, but at the end, I’ll try to open up the floor for some questions.
Disclaimer: I cannot recommend veterinary medicines for human use. You should seek the advice of your personal healthcare provider. Nothing in this discussion should be considered as medical advice. This is an educational forum. Medical advice should come from your trusted healthcare provider.
I was a prepper long before I was a prescriber. With that being said: Yes, I have taken fish antibiotics. I had stockpiles of them before I attained my prescriptive authority. They worked just the same. I still have these in my emergency kit, despite my having access to human versions. More on this later.
Medications are poisons we know the side effects of.
The best medicine is nothing. If something is likely to resolve on its own, it's best to avoid medication. All medications have side effects, and these side effects can vary from person to person.
Get yourself some guidance. Alton’s Antibiotics and Infectious Disease: The Layman’s Guide to Available Antibacterials in Austere Settings.
Epocrates will give you free access to basic prescribing information. There is also a paid version that is more expansive and detailed. This website is one of the resources I use for help with diagnosis and prescribing in the clinic.
What is pharmacology? The basic understanding of how medications work in the body.
Pharmacokinetics: the study of what the body does to a drug. It's like tracking how a drug gets into your body, moves around, and eventually leaves.
Mechanism of Action: This term is like understanding how a lock and key work. It tells us how a medicine does its job once it's in our body. Medicines are designed to interact with specific parts of our body, like proteins or receptors. When they find the right spot, they can either turn something on (like a light switch) or turn something off (like a TV remote). This action is what helps the medicine do what it's supposed to do, like relieving pain, fighting off germs, or fixing something that's not working well in our body. So, the "mechanism of action" is like uncovering the secret of how medicine works its magic inside us.
Absorption: This is the process where the drug gets into your bloodstream from the place where you took it, like swallowing a pill or getting a shot.
Distribution: After entering the bloodstream, the drug travels to different parts of your body, like your organs and tissues, to do its job.
Metabolism: This is when the drug changes into a different form in your body. Sometimes, the drug needs to be broken down to work better or to be removed from your body.
Excretion: This is how your body gets rid of the drug once it's done its job. It usually leaves your body through your urine or GI tract.
Half-life: This is like a timer that tells us how long it takes for half of the drug to leave your body. It helps doctors figure out how often you need to take a medicine. Rule of thumb: It generally takes 5 half-lives to eliminate a drug from the body. Consider this if you need to know how long it takes for the body to remove a medication. Ex: T1/2: 50% 2 T1/2 75% 3 ½ 87.5% etc.
Most medications are processed by the liver and excreted by the kidneys and the GI tract. Medication prescribing guidance will note dose adjustments for patients with kidney or liver disease. If you take a medication and your body cannot process it out, you may develop toxicity.
A couple of terms:
AGONIST: An agonist, in pharmacology, is a substance or drug that activates or stimulates a specific receptor in the body, often mimicking the effects of a natural chemical. This activation typically leads to a biological response or a specific physiological effect. Essentially, an agonist "turns on" a receptor to produce a desired outcome in the body. THINK GO.
ANTAGONIST, in pharmacology, is a substance or drug that opposes or blocks the activity of a specific receptor in the body. It prevents the receptor from being activated by natural chemicals or other substances, thereby inhibiting or reducing the receptor's normal function. In essence, an antagonist "turns off" or counteracts the effects of a receptor, often to achieve therapeutic goals or control biological processes. THINK ANTI GO OR STOP.
Reactions: I always say: any medication can cause any side effect in anyone. If you’ve started a medication and you have a new symptom, 95% of the time, it's due to the medication.
Medication reaction s/s:
The worst: Anaphylaxis. An immediate hypersensitivity reaction characterized by:
- Itchy hives or welts.
- Flushed or pale skin.
- Difficulty breathing or shortness of breath.
- Wheezing or coughing.
- Swelling of the throat, tongue, or lips, which can lead to airway constriction.
- Rapid or weak pulse.
- Low blood pressure, which can cause dizziness or fainting.
- Nausea or vomiting.
- Abdominal pain or cramping.
- Feeling of impending doom or anxiety.
- Confusion or altered mental state.
- Loss of consciousness.
RED FLAGS: Rapid progression of symptoms is an ominous sign: Rapid progression of symptoms, respiratory distress (eg, stridor, wheezing, dyspnea, increased work of breathing, persistent cough, cyanosis), vomiting, abdominal pain, hypotension, dysrhythmia, chest pain, collapse. This is a life-threatening emergency. It comes on fast, and there is little time to waste. Immediate medical stabilization is necessary. Expect treatments in the emergency department to include Epinephrine (often several doses and there are no contraindications to epinephrine with anaphylaxis), Oxygen, saline infusion, airway securement/intubation, albuterol, steroids, H1, H2 blockers. Continual monitoring is essential as the medications can wear off before anaphylaxis terminates.
For most simple reactions such as rash without the above symptoms, Benadryl can help to calm the sensitivity but it needs to be given every 6 hours. Continued treatment includes H1 blocker (claritin, zyrtec,) and H